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Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors

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Men receiving a 5-alpha reductase inhibitor (5-ARI) for treatment of benign prostatic hypertrophy who developed prostate cancer were more likely to have a delay in diagnosis as well as worse.

What Is the Prostate? What’s Normal? – A larger prostate doesn’t mean you’ll have more or worse symptoms. It’s different for each. and what’s called 5-alpha reductase inhibitors, or 5-ARIs, which help shrink the prostate. Many men may.

5-alpha reductase inhibitors For BPH Linked to Higher, Not Lower, PSA Levels.. A previous study called prostate cancer Prevention Trial. Outcomes of prostate cancer screening by 5-alpha reductase inhibitor usage Journal of Urology ISSN 0022-5347 Accepted/In press – 10 Feb 2017.

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5-alpha-reductase inhibitors delay prostate cancer diagnosis, worsen outcomes 19 days ago – By Healio. A recent study found prior use of 5-alpha-reductase inhibitors for benign prostatic hyperplasia was associated with delayed prostate cancer diagnosis and worse prostate cancer outcomes.

Finasteride and Prostate Cancer: A Commentary. The use of finasteride was associated with an increased risk of prostate and overall cancer (prostate cancer risk increased with an odds ratio of 1.9; overall cancer odds ratio was 1.5). Use of dutasteride was associated with no reduction in risk of prostate cancer and an increased risk of renal cancer.

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Use of 5-reductase inhibitors prior to prostate cancer diagnosis is. cancer- specific mortality rate was significantly higher among 5-ARI users than. may have resulted in advanced disease and worsened clinical outcomes.”.

 · This food is the third food/herb shown in human studies to be as effective as tamsulosin. In one German study, 12 months of treatment of pumpkin seed led to a clinically reduction in symptoms in men with prostate enlargement compared to placebo.

Because PSA levels are used to detect early-stage prostate cancer, men interested in taking a 5-alpha reductase inhibitor might consider the following: Most experts suggest that men be checked for the presence of prostate cancer (using the PSA test and a digital rectal exam) before taking 5-alpha reductase inhibitors.

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